SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes
نویسندگان
چکیده
منابع مشابه
SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation
Non-alcoholic-fatty-liver-disease (NAFLD) encompasses conditions associated to fat deposition in the liver, which are generally deteriorated during the aging process. MacroH2A1, a variant of histone H2A, is a key transcriptional regulator involved in tumorigenic processes and cell senescence, and featuring two alternatively splicing isoforms, macroH2A1.1 and macroH2A1.2. MacroH2A1.1 binds with ...
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ژورنال
عنوان ژورنال: npj Aging and Mechanisms of Disease
سال: 2017
ISSN: 2056-3973
DOI: 10.1038/s41514-017-0011-1